Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis inTrypanosoma cruzi
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چکیده
منابع مشابه
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged from 5.1 to 13.2 pmol/mg protein depending on the parasite strain and growth phase. Nifurtimox and benznidazole, used in the treatment of Chagas' disease, decreased metallothion...
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Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine thus far studied (Griffith, O.W., Anderson, M.E., and Meister, A. (1979) J. Biol. Chem. 254, 1205-1210), inhibited gamma-glutamylcysteine synthetase about 20 times more effectively than did prothionine sulfoximine and at least 100 times more effectively than methionine s...
متن کاملButhionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.
l-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole toward the epimastigote, trypomastigote, and amastigote forms of Trypanosoma cruzi. BSO at 500 muM decreased total glutathione-derived thiols by 70 to 80% in 48 h. In epimastigotes, 500 muM BSO decreased the concentration of nifurtimox needed to inhibit constant growth of the parasites by 50%, from 14.0 t...
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23 Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamylcysteine synthetase, thus 24 blocking the synthesis of glutathione (GSH). It is known that this makes that BSO affects melanin 25 synthesis because of the role of thiols in melanogenesis. However, BSO may also react with the 26 intermediate oxidation products of melanogenesis, a possibility that has not been investigated from ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2017
ISSN: 0014-5793
DOI: 10.1002/1873-3468.12904